Assigning R & S configuration based on Cahn Ingold & Prelog system.

Dr. Rojisha V. C.'s and Dr. Rahul Soman's online class on R-S Notation as per Graduate Pharmacy apptitude test syllabus topic covers Stereoisomerism part IV, discuss about



   -  R-S (Rectus and Sinister) Naming System

   -  CIP (Cahn, Ingold, Prelog) system

   -  Sequence rules or CIP rules

   -  Designing and Asigning Absolute configuration

   -  Priorities

   -  R-S nomenclature of a chirality center

   -  Problem solving with R S Notation

   -  Absolute Configurations of Fischer Projections

   -  R,S nomenclature in Wedge representation with more than one asymmetric carbon

   -  R-S configuration in Fischer Projections with more than one asymmetric carbon



Online Lecture in English

GPAT Syllabus/ Organic chemistry / Stereochemistry

11. Stereochemistry

Stereochemistry. Chirality & asymmetry [introduction of the same to S, P, & N]. Definition & classification [different types of isomerisms]. Enantiomers, diastereomers. Enantiomerism & diastereomerism. Meso compounds & their optical activity. Stereochemistry in acyclic compounds. Newman projection formulae & their significance. Conformational analysis of nbutane. Absolute & relative configuration. Assigning R & S configuration based on Cahn Ingold & Prelog system. Racemic mixture- its definition & resolution. Definitions of terms stereoselective, stereospecific, Enantiomeric excess & diastereomeric excess. Stereochemistry in cyclic systems. Conformations of cyclohexane. Cis-trans relationship in cyclohexane. Prediction of stability of different conformations of 1, 2- 1,3- & 1,4- disubstituted cyclohexanes. Effect of multiple substitutions on the stability of cyclohexane conformations. Chair conformations of cis-, & trans-decalins, perhydrophenanthrenes, & a tetracyclic steroidal nucleus. An introduction to atropisomerism.

 

Lecture 1: Stereochemistry : Definition & classification [different types of isomerisms].

Lecture 2: Stereochemistry: Stereochemistry in acyclic compounds.  Newman projection formulae & their significance.

Lecture 3: Stereochemistry: Chirality & asymmetry [introduction of the same to S, P, & N]. Enantiomers, diastereomers. Enantiomerism & diastereomerism. Meso compounds & their optical activity.

Lecture 4: Stereochemistry:  relative configuration & Stereochemistry in cyclic systems.

Lecture 5: Stereochemistry: Assigning R & S configuration based on Cahn Ingold & Prelog system.

Lecture 6: Stereochemistry: Conformational analysis of nbutane. Absolute

Lecture 7: Stereochemistry: Conformations of cyclohexane. Cis-trans relationship in cyclohexane. Prediction of stability of different conformations of 1, 2- 1,3- & 1,4- disubstituted cyclohexanes. Effect of multiple substitutions on the stability of cyclohexane conformations.